At 08:40 UTC on 2018-10-11, Soyuz MS-10 launched toward the International Space Station with a crew of two on board: Commander Aleksey Ovchinin of the Russian Space Agency and Flight Engineer Nick Hague of NASA.
Shortly after the separation of the four first stage boosters, around two minutes into the flight, Russian mission control began to report “failure”. The animation shown on NASA TV continued to show a nominal mission. There were several additional reports of failure, including the time.
Shortly thereafter, Ovchinin reported a ballistic re-entry had been selected, and then that they were weightless. Then, he reported G forces building to 6.5 (consistent with a steep ballistic re-entry), and then declining to something over two [I think 2.5 or 2.7, but I do not have a recording], which would indicate having passed through the peak of re-entry braking.
There have been no reports from the crew since then. Russian mission control reports that recovery helicopters have been dispatched to the predicted landing zone, and are expected to take around 90 minutes to arrive. The launch was on a northeast azimuth, so landing would be expected to be in northern Russia.
After a long delay (presumably because the descent capsule had passed over the horizon from the tracking stations), rescue forces reported that they had contacted the crew by radio. The crew reported that they had landed and were in good condition.
I will add updates in the comments as events unfold.